Aceclofenac 200 mg sustained release (SR) Tablet Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions...

HETROFEN 200 SR Tablet

Each Film Coated Sustained Release Tablet Contains Aceclofenac IP 200 mg.

Hetrofen 200 SR Tablet contains Aceclofenac 200 mg in a sustained-release formulation, primarily used for its anti-inflammatory and analgesic properties.

Uses & Indications:

Hetrofen 200 SR is prescribed for:

• Osteoarthritis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Other inflammatory conditions causing pain and swelling

Mechanism of Action

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes, particularly COX-2. This action reduces the production of prostaglandins, which are chemicals responsible for inflammation, pain, and fever, thereby alleviating symptoms associated with inflammatory conditions.

Dosage

• Standard Dose: 200 mg once daily

• Administration: Take with food or milk to minimize gastrointestinal discomfort

• Missed Dose: If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose—do not double the dose.

Side Effects

Common side effects may include:

• Indigestion

• Heartburn

• Nausea

• Diarrhea

• Abdominal pain

• Flatulence

Serious side effects are rare but can include gastrointestinal bleeding or ulcers, especially with prolonged use .

Contraindications

Do not use Hetrofen 200 SR if you have:

• Hypersensitivity to Aceclofenac or other NSAIDs

• Active or history of gastrointestinal bleeding

• Severe renal or hepatic impairment

• Third trimester of pregnancy

Use with caution in individuals with:

• Peptic ulcer disease

• Cardiovascular disorders

• Systemic lupus erythematosus

• Porphyria

Drug Interactions

Potential interactions include:

• Anticoagulants (e.g., warfarin): Increased risk of bleeding

• Diuretics: Reduced effectiveness

• Methotrexate: Elevated methotrexate levels leading to toxicity

• Lithium and Digoxin: Increased plasma concentrations

• Quinolones: Risk of convulsions when combined with NSAIDs

For Use of Registered Medical Practitioner or A Hospital Only

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