HETROFEN 100 TABLET
Aceclofenac 100 MG SR Tablet (HETROFEN 100) is a pain-relieving medicine
HETROFEN 100 TABLET
Aceclofenac 100 MG sustained release (SR) tablet
Aceclofenac 100 Tablet belongs to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used for short term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis.
HETROFEN 100 SR TABLET
It is a phenyl acetic acid derivative showing effective anti-inflammatory and analgesic properties, and a good tolerability profile in a variety of painful conditions.
Aceclofenac has been shown to exert effects on many mediators of inflammation.
It inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. In vitro data indicate inhibition of cyclo-oxygenase by aceclofenac in whole blood assays, with selectivity for COX-2 being evident.
A unique feature of aceclofenac's pharmacology is that it, unlike diclofenac and some other NSAIDs, stimulates glycosaminoglycans (GAG) synthesis.
Indications/ use of Aceclofenac 100 (HETROFEN 100 SR TABLET)
For the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
Dosage of Aceclofenac 100 Tablet (HETROFEN 100 SR TABLET)
100mg orally b.i.d. Dosage reductions are recommended in patients with hepatic impairment, with a suggested initial dosage of 100mg/day.
Contra-Indications of Aceclofenac 100 Tablet (HETROFEN 100 SR TABLET)
Hypersensitivity, GI bleeding, moderate to severe renal impairment, last three months of pregnancy
Special Precautions of Aceclofenac 100 Tablet (HETROFEN 100 SR TABLET)
Patients with GI disease, history of peptic ulceration, cerebrovascular bleeding, ulcerative colitis, Crohn's disease, systemic lupus erythmatosus, porphyria, hematopoietic or coagulation disorders. The dose should be reduced in patients with mild to moderate hepatic, renal or cardiac function impairment.
Side Effects of Aceclofenac 100 Tablet (HETROFEN 100 SR TABLET)
Indigestion, heartburn, dyspepsia, diarrhoea, nausea, abdominal pain and flatulence.
Drug Interactions of Aceclofenac 100 Tablet (HETROFEN 100 SR TABLET)
Aceclofenac may increase the plasma conc. of lithium and digoxin. Aceclofenac may inhibit the activity of diuretics. Activity of anticoagulants may be enhanced. Convulsions may occur due to interaction between quinolones and NSAIDs.
For Use of registered medical practitioner or a hospital only