Cefixime and Potassium Clavulanate Tablets – ROVIXIM CLAV Tablet

Cefixime and potassium clavulanate tablets are a widely prescribed combination antibiotic therapy used for the effective treatment of resistant bacterial infections. This formulation combines a third-generation cephalosporin with a beta-lactamase inhibitor, offering enhanced antibacterial coverage against a broad range of gram-positive and gram-negative pathogens.The addition of clavulanate helps overcome bacterial resistance mechanisms, improving treatment success in infections where single-agent therapy may be insufficient.

ROVIXIM CLAV Tablet is a well-balanced oral antibiotic developed to meet modern clinical needs. Manufactured by Green Cross Remedies, it is designed to deliver consistent efficacy, safety, and patient compliance in the management of common to moderately severe bacterial infections.

Product Composition

Each film-coated tablet contains:

• Cefixime I.P. (as Trihydrate) – 200 mg (Equivalent to Anhydrous Cefixime)
• Potassium Clavulanate I.P. – 125 mg (Equivalent to Clavulanic Acid)

Uses of Cefixime and Potassium Clavulanate Tablets

Cefixime and potassium clavulanate tablets are used in the treatment of a wide range of bacterial infections caused by susceptible organisms.

Cefixime and potassium clavulanate tablets uses include:

• Upper and lower respiratory tract infections
• Acute bacterial sinusitis
• Otitis media (ear infections)
• Urinary tract infections
• Skin and soft tissue infections
• Typhoid fever and enteric infections (as advised by a physician)
• Tonsillitis
• Pharyngitis
• Pneumonia
• Sexually Transmitted Infections (STI): Such as gonorrhea.
• Acute exacerbation of chronic bronchitis
• Typhoid & Paratyphoid Fever

This combination is often preferred when beta-lactamase–producing bacteria are suspected, ensuring improved clinical outcomes.

ROVIXIM CLAV is an antibiotic medication primarily used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, and skin infections. It is effective against both gram-positive and gram-negative bacteria.

Indications

ROVIXIM CLAV Tablet is indicated for infections caused by cefixime-sensitive organisms, particularly where resistance to standard cephalosporins is a concern. It is commonly prescribed for:

• Bronchitis and pneumonia
• Tonsillitis and pharyngitis
• Complicated urinary tract infections
• Bacterial gastrointestinal infections
• Mixed bacterial infections requiring broader coverage

Mechanism of Action

• Cefixime is a third-generation cephalosporin that works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. However, some bacteria produce beta-lactamase enzymes that can inactivate cephalosporins.
• Clavulanic acid, present as potassium clavulanate, inhibits these beta-lactamase enzymes. This protective action enhances the activity of cefixime, making cefixime clavulanic acid tablets effective against resistant bacterial strains and extending their antibacterial spectrum.
• This combination works synergistically to kill bacteria:

Dosage and Administration

The dosage of cefixime potassium clavulanate tablets depends on the severity of infection, patient age, renal function, and clinical response.

General guidelines:

• Administer as prescribed by a healthcare professional
• Usually taken once or twice daily
• Preferably taken after food to minimize gastric discomfort
• Do not crush or chew film-coated tablets

Patients should complete the full course of therapy even if symptoms improve early.

Side Effects

Most patients tolerate cefixime clavulanate tablets well. However, some may experience mild to moderate side effects.

Common side effects include:

• Diarrhea
• Nausea or vomiting
• Abdominal pain
• Headache

Rare but serious reactions include hypersensitivity reactions, severe diarrhea, or liver enzyme elevations. Immediate medical attention is required if allergic symptoms occur.

Contraindications and Precautions

• Contraindicated in patients with known hypersensitivity to cephalosporins or clavulanic acid
• Use with caution in patients with a history of penicillin allergy
• Dose adjustment may be required in renal impairment
• Prolonged use may increase the risk of superinfection

Always consult a physician before starting treatment.

Drug Interactions

Cefixime and clavulanate may interact with:

• Anticoagulants (may increase bleeding risk)
• Probenecid (may increase cefixime levels)
• Oral vaccines (reduced efficacy)

Inform the physician about all concurrent medications.

Storage Instructions

• Store below 25°C
• Protect from moisture and direct sunlight
• Keep tablets in original packaging
• Keep out of reach of children

Cefixime and Potassium Clavulanate Tablet Price – ROVIXIM CLAV Tablet (MRP): 196.59

Expert Advice

• Cefixime I.P. (as Trihydrate) 200 mg and Potassium Clavulanate I.P. 125 mg should always be taken exactly as prescribed by a healthcare professional.
• Avoid skipping doses and do not discontinue therapy prematurely, even if symptoms improve, as this may lead to treatment failure or antibiotic resistance.
• Antibiotics should never be self-medicated or shared with others. Adequate hydration and timely reporting of adverse effects help ensure safe and effective treatment.
• Take the tablet with food to minimize gastric upset. Discontinue the medicine and seek immediate medical attention if rash, itching, swelling of the face or mouth, or breathing difficulty occurs.
• Avoid alcohol consumption during therapy, as it may increase side effects.

Rovixim Clav Tablet by Green Cross Remedies is a reliable cefixime and potassium clavulanate tablets formulation from a trusted leading antibiotic manufacturer in India. Manufactured in a WHO-GMP certified facility, it ensures consistent quality, proven efficacy, and dependable therapeutic outcomes, making it a preferred choice for healthcare professionals in managing bacterial infections.

Disclaimer:

This information is intended for the use of Registered Medical Practitioners, Hospitals, Medical Stores, Pharma Agencies, Healthcare Professionals, Pharmaceutical Company Field Staff, and Pharmacies Only.

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