GC PRIDE INJECTION

GC PRIDE INJECTION

Levosulpiride 12.5 mg Injection

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AZIGO 100 DT Tablet

GC PRIDE INJECTION

Levosulpiride 12.5 mg Injection

 

Levosulpiride

It is a substituted benzamide antipsychotic which is reported to be a selective antagonist of central dopamine (D-2, D-3 & D-4) receptors, also have mood elevating properties.

INDICATIONS OF LEVOSULPIRIDE 12.5MG:

  • ANXIETY,
  • DEPRESSION,
  • PSYCHOSES SUCH AS SCHIZOPHRENIA,
  • VERTIGO
  •  PEPTIC ULCERATIONS.

SIDE EFFECTS OF LEVOSULPIRIDE 12.5MG:

  • AMENORRHOEA,
  • GYNAECOMASTIA,
  • GALACTORRHOEA,
  • CHANGES IN LIBIDO.
  • POTENTIALLY FATAL:
  • NEUROLEPTIC MALIGNANT SYNDROME.

DRUG INTERACTIONS OF LEVOSULPIRIDE 12.5MG:

REDUCED BIOAVAILABILITY WITH SUCRALFATE, ALUMINIUM- AND MAGNESIUM-CONTAINING ANTACIDS. EFFECT ON GI MOTILITY MAY BE ANTAGONISED BY ANTICHOLINERGIC AGENTS, NARCOTICS AND ANALGESICS. AVOID ALCOHOL.

CONTRAINDICATIONS OF LEVOSULPIRIDE 12.5MG:

  • PHAEOCHROMOCYTOMA,
  • EPILEPSY,
  • MANIC STATES,
  • HYPERPROLACTINAEMIA,
  • MAMMARY DYSPLASIA,
  • MALIGNANT MASTOPATHIES,
  • CARDIAC IMPAIRMENT.
  • GI BLEEDING,
  • MECHANICAL OBSTRUCTION OR PERFORATION.

MECHANISM OF ACTION OF LEVOSULPIRIDE 12.5MG:

LEVOSULPIRIDE IS A SUBSTITUTED BENZAMIDE, WHICH EXERTS ANTIDOPAMINERGIC (SELECTIVE DOPAMINE D2 RECEPTORS) ACTIVITY ON BOTH CENTRAL AND PERIPHERAL LEVELS. IT IS AN ATYPICAL NEUROLEPTIC AND A PROKINETIC AGENT. ABSORPTION: ORAL BIOAVAILABILITY IS ABOUT 30%; PEAK PLASMA CONCENTRATIONS AFTER ABOUT 3 HR. EXCRETION: MAINLY VIA URINE. PLASMA HALF-LIFE: 9.7 HR (ORAL); 4.3 HR (IV).

SPECIAL PRECAUTIONS FOR LEVOSULPIRIDE 12.5MG:

MAY IMPAIR ABILITY TO DRIVE OR OPERATE MACHINERY. PREGNANCY AND LACTATION.

PATIENTS RECEIVING ANTIHYPERTENSIVE, HYPNOTIC & ANALGESIC DRUGS, BECAUSE CONCURRENT USE MAY INCREASE THE EFFECTS OF THESE DRUG.

 

For Use of Registered Medical Practitioner or a Hospital Only.