JORONAC MR Tablet
Diclofenac Potassium,Paracetamol,Chlorzoxazone Tablet (JORONAC MR) Useful In Pain, Inflammation, Fever, Swelling, As Muscle Relaxant
JORONAC MR Tablet
Each Film Coated Tablet Contains:
Diclofenac Potassium 50 mg, Paracetamol 325 mg,Chlorzoxazone 250 mg
Diclofenac Potassium
It is a non-steroidal anti-inflammatory, analgesic & antipyretic, drug. Diclofenac inhibits prostaglandin synthesis by interfering with the action of prostaglandin synthetase which explains its action.
It is ideally suited for patients on sodium free diet, hypertensive patients, to treat painful inflammatory conditions of patients on diuretic therapy.
Indications/Use of Diclofenac Potassium
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Post operative & Post traumatic inflammation
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muscular and skeletal pain and other co-existing conditions like spondylitis, Rheumatoid arthritis & Osteoarthritis
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Painful inflammatory conditions in Gynaecology
Dosage of Diclofenac Potassium
50mg 3 times daily.
Contra-Indications of Diclofenac Potassium
Peptic ulcer, known hypersensitivity to the active substances, acetyl salicylic acid or other prostaglandin synthetase inhibiting drugs.
Paracetamol
(Acetaminophen)Paracetamol is a valuable central analgesic but weak peripheral anti-inflammatory agent & exhibits good & prompt antipyretic action. It does not stimulate respiration, or alter acid base balance & causes less gastric irritation & have no effect on cellular metabolism or clotting factors. It is not uricosuric.
Indications/Use of Paracetamol
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Pain
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fever
Dosage of Paracetamol
325 MG -1 GM upto 4 gm daily in divided doses.
Special Precautions of Paracetamol
Renal and hepatic impairment.
Side Effects of Paracetamol
Nausea, Rashes, leucopenia is rare.
Drug Interactions of Paracetamol
Enhances oral anticoagulant activity. Absorption increased by metoclopramide. Absorption reduced by pethidine, propanthline. Alcohol (chronic use) potentiates hepatotoxicity by paracetamol.
Chlorzoxazone
This compound is chemically unrelated to mephenesin and the other relaxants, nevertheless its pharmacological actions and uses are similar to them.
Indications/Use of Chlorzoxazone
Skeletal muscle spasms
Dosage of Chlorzoxazone
250-750 mg, 3-4 times daily.
Contra-Indications of Chlorzoxazone
Hypersensitivity, pregnancy
Special Precautions of Chlorzoxazone
Discontinue if symptoms of liver dysfunction occur. Paediatrics: Reduced dose is necessary. Pregnancy: Safety not established. Lactation: Use with caution and only if clearly indicated. Elderly: No special problem.
Side Effects of Chlorzoxazone
Gastro intestinal irritation, headache, lethargy.
Drug Interactions of Chlorzoxazone
CNS effects enhanced by other CNS depressants such as alcohol.
For Use of Registered Medical Practitioner or A Hospital Only