Piperacillin and Tazobactam Injection – GROSYN TZ 4.5 Injection

• Piperacillin and tazobactam injection is a widely prescribed broad-spectrum antibiotic used in the treatment of moderate to severe bacterial infections.
• It combines a penicillin-class antibiotic (piperacillin) with a beta-lactamase inhibitor (tazobactam), making it highly effective against resistant bacteria.
• GROSYN TZ 4.5 Injection contains Piperacillin 4 gm and Tazobactam 500 mg, formulated to provide reliable and rapid antibacterial action in hospitalized patients. 
• GROSYN TZ 4.5 Injection by Green Cross Remedies is a broad spectrum Piperacillin and Tazobactam injection containing Piperacillin 4 gm and Tazobactam 500 mg. It is indicated for severe bacterial infections including pneumonia, septicemia, intra-abdominal infections, and complicated UTIs, ensuring reliable hospital-grade antibacterial therapy.
• This advanced injectable antibiotic is designed to meet stringent quality standards and is intended for use under medical supervision.

Composition

Each vial contains:

• Piperacillin – 4 gm
• Tazobactam – 500 mg
• Sterile formulation for intravenous use

This strength is commonly referred to as piperacillin tazobactam 4.5 g, a standard hospital dose used globally.

Uses & Indications

Piperacillin and tazobactam injection uses include treatment of serious infections caused by susceptible organisms. It is frequently prescribed for:

• Lower respiratory tract infections (including pneumonia)
• Urinary tract infections (complicated cases)
• Intra-abdominal infections
• Skin and soft tissue infections
• Gynecological infections
• Septicemia (bloodstream infections)
• Hospital-acquired infections
• Severe bacterial infections

As a Piperacillin Tazobactam antibiotic injection, it is especially valuable in ICU settings where broad-spectrum coverage is required before culture results are available.

Indications:

This injectable medication is indicated for use in patients with:

• Complicated infections where resistant strains are present
• Patients requiring broad-spectrum antibiotic coverage

Mechanism of Action

• Piperacillin works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. However, many bacteria produce enzymes called beta-lactamases that can inactivate antibiotics.
• Tazobactam protects piperacillin by inhibiting these beta-lactamase enzymes. This synergistic action enhances effectiveness against resistant organisms, making it a powerful broad spectrum antibiotic injection.

Dosage & Administration

Piperacillin tazobactam dosage and administration should always be determined by a physician based on the severity of infection, renal function, and patient condition.

• Common adult dose: 4.5 g every 6–8 hours (IV infusion)
• Dose adjustments required in renal impairment
• Administer via slow intravenous infusion over 30 minutes

The reconstituted solution should be used promptly as per hospital protocol.

Side Effects

Like all antibiotics, piperacillin tazobactam side effects may occur in some patients.

Common side effects:

• Nausea or vomiting
• Diarrhea
• Injection site reactions
• Headache

Less common but serious effects:

• Allergic reactions (rash, itching, swelling)
• Severe diarrhea (possible C. difficile infection)
• Electrolyte imbalance
• Abnormal liver function tests

Immediate medical attention is required in case of severe hypersensitivity reactions.

Contraindications & Precautions

This medication should be avoided in patients with:

• Known hypersensitivity to penicillins or beta-lactam antibiotics
• Severe allergic reactions to cephalosporins

Use with caution in:

• Renal impairment
• Liver dysfunction
• Elderly patients
• Patients with bleeding disorders

Regular monitoring of kidney function and electrolytes is recommended during prolonged therapy.

Drug Interactions

Piperacillin and tazobactam uses may be affected by certain medications:

• Aminoglycosides
• Anticoagulants
• Methotrexate
• Probenecid

Concurrent use with nephrotoxic drugs should be monitored carefully.

Storage Instructions

• Store below 25°C
• Protect from light and moisture
• Keep out of reach of children
• Use reconstituted solution immediately or as per institutional guidelines

Piperacillin and Tazobactam Injection price – GROSYN TZ 4.5 Injection (MRP): 426.56

Expert Advice

• Piperacillin 4 gm and Tazobactam 500 mg Injection should always be administered exactly as prescribed by a qualified healthcare professional.
• Do not skip doses or discontinue therapy prematurely, even if symptoms improve, as incomplete treatment may contribute to antibiotic resistance.
• To achieve optimal therapeutic outcomes with piperacillin tazobactam 4.5 g, strict adherence to dosing schedules is essential.
• This injection is intended for hospital use and should never be self-administered.
• Adequate hydration and regular monitoring of renal function are recommended during therapy.
• Inform your doctor immediately if you experience rash, breathing difficulty, persistent diarrhea, or unusual bleeding.
• Avoid unnecessary antibiotic use to help preserve future treatment effectiveness.

Frequently Asked Questions (FAQs)

What are piperacillin tazobactam injection uses in hospitals?

• It is used for severe bacterial infections such as pneumonia, abdominal infections, septicemia, and complicated UTIs.

Is piperacillin and tazobactam injection safe for severe bacterial infections?

• Yes, when administered under medical supervision, it is considered highly effective for serious infections.

What is the standard strength of Piperacillin 4 gm Tazobactam 500 mg injection?

• The commonly prescribed hospital dose is 4.5 g (4 gm + 500 mg) given intravenously.

Who is a reliable Piperacillin Tazobactam manufacturer in India?

• Green Cross Remedies manufactures GROSYN TZ 4.5 Injection, ensuring high-quality standards and compliance with regulatory

norms.

How long is the treatment duration?

• Treatment duration depends on infection severity, typically ranging from 5 to 14 days as advised by the physician.

What is the piperacillin and tazobactam injection price in India?

• The price varies depending on region and distribution. Contact Green Cross Remedies for the latest pricing details.

Piperacillin and tazobactam injection, marketed under the brand name GROSYN TZ 4.5 Injection, is manufactured by Green Cross Remedies, a trusted pharmaceutical company committed to quality and safety. This formulation contains Piperacillin 4 gm and Tazobactam 500 mg injection, developed to deliver dependable antibacterial coverage in serious infections. Produced in a WHO-GMP compliant facility, it ensures consistent potency, sterility, and therapeutic reliability for hospital and critical care use.

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