MECHANISM OF ACTION OF CLOTRIMAZOLE 1%:

CLOTRIMAZOLE IS A BROAD-SPECTRUM ANTIFUNGAL WHICH BINDS TO PHOSPHOLIPIDS IN THE CELL MEMBRANE ALTERING CELL WALL PERMEABILITY CAUSING A LOSS IN ESSENTIAL INTRACELLULAR ELEMENTS. ABSORPTION: NEGLIGIBLE THROUGH INTACT SKIN (TOPICAL); 3-10% (VAGINAL). METABOLISM: HEPATIC; CONVERTED TO INACTIVE METABOLITES. EXCRETION: URINE, FAECES (AS METABOLITES).

SIDE EFFECTS OF CLOTRIMAZOLE 1%:

TOPICAL: ERYTHEMA, STINGING, IRRITATION; HYPERSENSITIVITY REACTIONS; CONTACT DERMATITIS. ORAL: GI DISTURBANCES, DYSURIA, MENTAL DEPRESSION, ELEVATED LIVER ENZYMES.

DRUG INTERACTIONS OF CLOTRIMAZOLE 1%:

ANTAGONISM WITH POLYENE ANTIBIOTICS.

CONTRAINDICATIONS OF CLOTRIMAZOLE 1%:

HYPERSENSITIVITY.