ROZUSTEEN -20 Tablet
ROZUSTEEN -20 Tablet
COMPOSITION:
Each film coated tablet contains:
Rosuvastatin Calcium ip eq to Rosuvastatin 20 mg
Rosuvastatin
It is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol. The primary site of action of rosuvastatin is the liver, the target organ for cholesterol lowering. Rosuvastatin increases the number of hepatic LDL receptors on the cell-surface, enhancing uptake and catabolism of LDL and it inhibits the hepatic synthesis of VLDL, thereby reducing the total number of VLDL and LDL particles.
Indications -Use of Rosuvastatin 20 Tablet (ROZUSTEEN -20 Tablet):
Primary hypercholesterolaemia (type IIa including heterozygous familial hypercholesterolaemia) or mixed dyslipidaemia (type IIb), including familial hypercolesterolaemia.
Dosage of Rosuvastatin 20 Tablet(ROZUSTEEN -20 Tablet):
The recommended starting dose is 10 mg orally once daily. A dose adjustment to 20mg can be made after 4 weeks .
Contra-Indications of Rosuvastatin 20 Tablet(ROZUSTEEN -20 Tablet):
Severe renal impairment, active liver disease, hypersensitivity to rosuvastatin, myopathy, cyclosporin, pregnancy and lactation .
Side Effects of Rosuvastatin 20 Tablet (ROZUSTEEN -20 Tablet):
Headache, dizziness, constipation, nausea, abdominal pain, myalgia and asthenia.
Drug Interactions of Rosuvastatin 20 Tablet (ROZUSTEEN -20 Tablet):
Cyclosporin, warfarin, gemfibrozil, erythromycin, antacids, oral contraceptive/hormone replacement therapy (HRT).
For Use of registered medical practitioner or a hospital only