ZARBERA-N Tablet

Norethisterone 5 mg Tablet Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions..

ZARBERA-N Tablet (Norethisterone 5 mg Tablet)

 Norethisterone is used in heavy menstrual bleeding, pain during menstruation, endometriosis and Premenstrual syndrome (PMS).

Norethisterone regulates menstrual cycles and treats a wide range of menstrual disorders such as heavy, painful periods and endometriosis.

It may cause bleeding or spotting in between menstrual periods. Let your doctor know if this occurs frequently.

Norethisterone is a synthetic form of the hormone progesterone. It is commonly used in various gynecological and hormonal conditions.

Uses & Indications of Norethisterone 5 mg Tablet:

1. Menstrual Disorders:

   • Treatment of heavy menstrual bleeding (menorrhagia)

   • Painful periods (dysmenorrhea)

   • Irregular menstrual cycles

2. Premenstrual Syndrome (PMS): Relieves premenstrual symptoms.

3. Endometriosis: Alleviates symptoms by suppressing endometrial tissue growth.

4. Delayed Menstruation: Used to delay periods for personal or medical reasons.

5. Hormone Replacement Therapy (HRT): In combination with estrogen to reduce the risk of endometrial hyperplasia.

Dosage of Zarbera N Tablet:

• Menstrual Disorders: Typically 5 mg taken 2–3 times daily.

• Delayed Menstruation: Start 3 days before the expected period and continue as directed by your doctor.

• Endometriosis: 5–15 mg daily, depending on the severity and treatment response.

• HRT: Dose varies depending on the regimen.

Always follow the prescribing doctor's instructions for specific dosages.

Mechanism of Action of Zarbera N Tablet:

Norethisterone mimics the action of natural progesterone. 

• Modifies the uterine lining (endometrium) to prevent overgrowth.

• Suppresses ovulation when used in higher doses.

• Alters the cervical mucus, making it less suitable for sperm penetration.

Side Effects of Norethisterone 5 mg Tablet:

Common side effects include:

• Nausea or vomiting

• Breast tenderness

• Headache

• Mood changes (irritability, depression)

• Weight changes

• Acne or skin changes

• Irregular spotting or breakthrough bleeding

Rare or serious side effects:

• Blood clots (deep vein thrombosis, pulmonary embolism)

• Stroke or heart attack (especially in high-risk individuals)

• Severe allergic reactions (rash, swelling, difficulty breathing)

Contraindications of Norethisterone 5 mg Tablet:

• Known or suspected pregnancy

• Breast cancer or a history of hormone-dependent cancers

• Undiagnosed vaginal bleeding

• Severe liver disease

• History of blood clots or thrombophilia

• Porphyria

Drug Interactions of Zarbera N Tablet:

Norethisterone may interact with:

• Enzyme-inducing drugs: Rifampicin, carbamazepine, phenytoin, and barbiturates may reduce its efficacy.

• Antiretrovirals: Some HIV medications can alter its metabolism.

• Antifungals: E.g., ketoconazole may increase its levels.

• Herbal products: St. John's Wort can reduce its effectiveness.

Always inform your doctor about any medications or supplements you are taking. 

For Use of Registered Medical Practitioner or A Hospital Only

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