Ketoconazole 2 %,Cetrimide 0.5 % Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions....

Green Cross Remedies: ZOYA Soap

Active Ingredients:

Ketoconazole 2%

Cetrimide 0.5%

Total Fatty Matter (TFM): 76%

Grade: 1 Soap

Weight: 75 gm

Active Ingredients and Their Functions:

• Ketoconazole (2%): Ketoconazole is an antifungal agent that inhibits the growth of fungi by interfering with the production of ergosterol, a crucial component of fungal cell membranes. This action helps in treating fungal infections of the skin, scalp, and hair.
• Cetrimide (0.5%): Cetrimide is a mild antiseptic that acts as a surfactant and disinfectant. It has cleansing properties and helps in preventing infections caused by bacteria.

Use & Indication:

ZOYA Soap is typically used for:

• Fungal Infections: It is primarily used for treating skin fungal infections like tinea versicolor, ringworm, athlete’s foot, and seborrheic dermatitis.
• Dandruff Control: It is often used for controlling dandruff and related scalp conditions caused by fungal infections (e.g., seborrheic dermatitis).
• Antiseptic: It can be used to cleanse minor cuts, wounds, and skin abrasions, preventing bacterial infections due to the presence of Cetrimide.

Side Effects:

Though ZOYA Soap is generally considered safe, some possible side effects include:

• Skin Irritation: Redness, itching, or burning sensation on the skin.
• Allergic Reactions: Skin rashes, swelling, or hives (though rare).
• Dry Skin: Excessive use can cause dryness or peeling of the skin.
• Contact Dermatitis: In rare cases, prolonged use may cause dermatitis.

If any severe reaction or discomfort occurs, discontinue use and consult a healthcare provider.

Dosage:

• For Skin Infections: Use the soap to cleanse the affected area once or twice a day, depending on the severity of the infection.
• For Dandruff: Use it as a scalp cleanser, applying it to damp hair and massaging gently before rinsing off.
• For Hygiene: For general use, it can be used as a regular body soap for washing and disinfecting.

Mechanism of Action:

• Ketoconazole works by inhibiting an enzyme called lanosterol demethylase, which is involved in the synthesis of ergosterol, a critical component of the fungal cell membrane. This disruption damages the fungal cell membrane, leading to the death of the fungal cell.
• Cetrimide is a quaternary ammonium compound that acts as a surfactant and antimicrobial agent. It works by disrupting the cell membrane of bacteria, leading to their destruction.

Contraindications:

• Allergic Reaction to Ketoconazole or Cetrimide: Individuals with a known allergy to either of the active ingredients should avoid using the soap.
• Open Wounds: It is not recommended for use on large open wounds or severely damaged skin without medical advice.
• Children: Use cautiously in young children, especially if there are any skin conditions or sensitivity issues. Consult a pediatrician before use.

Drug Interactions:

Although ZOYA Soap is a topical application, drug interactions can still occur indirectly. For example:

• Topical Corticosteroids: If used alongside topical steroids, there may be a reduced effectiveness of Ketoconazole in treating fungal infections.
• Other Antifungal Agents: If combined with other antifungal treatments, the risk of skin irritation may increase.
• Allergic or Skin Sensitizing Drugs: The presence of Cetrimide might increase the potential for skin reactions if used with other harsh skin products or drugs that make the skin sensitive.

It is always a good idea to consult a healthcare provider before using ZOYA Soap in combination with other medications.

For Use of registered medical practitioner or a hospital only

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