Ondansetron 2 mg / 1ml (2 ml) Injection Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions...

DOVION  Injection

Protects from nausea and vomiting

Use of DOVION  Injection:
Ondansetron is an antiemetic medication primarily used to prevent and treat nausea and vomiting. It is commonly administered in cases of:

• Chemotherapy-induced nausea and vomiting (CINV).

• Radiation-induced nausea and vomiting.

• Postoperative nausea and vomiting (PONV).

• Nausea and vomiting caused by other medical conditions or treatments.

Indications of Ondansetron Injection:

• Cancer treatment-related nausea: To prevent nausea and vomiting caused by chemotherapy or radiotherapy.

• Post-surgery nausea: For patients experiencing or at risk of nausea and vomiting following surgery.

• anesthesia

• G.I infections

• Radiotherapy

• Gastric dysmotality

• Morning sickness

Side Effects of DOVION  Injection:
Common side effects include:

• Headache.

• Fatigue or malaise.

• Dizziness.

• Constipation.

• Diarrhea.
  Less common but serious side effects:

• Prolonged QT interval (may lead to arrhythmias like Torsades de Pointes).

• Allergic reactions (rash, itching, or swelling).

• Blurred vision or temporary blindness (rarely after IV use).

Dosage of Ondansetron Injection:
Dosage varies depending on the indication:

• Chemotherapy-Induced Nausea and Vomiting (CINV):
  Adults: 8 mg administered intravenously or orally 30 minutes before chemotherapy.

• Postoperative Nausea and Vomiting (PONV):
  Adults: 4 mg administered intravenously as a single dose just before anesthesia or surgery.

• Pediatric dose: Depends on the child’s weight and condition. Always follow the doctor’s guidance.

Note: Maximum daily dose should not exceed 16 mg intravenously due to the risk of QT prolongation.

Mechanism of Action of DOVION  Injection:
Ondansetron works by antagonizing 5-HT3 (serotonin) receptors in both the central nervous system (in the chemoreceptor trigger zone) and the gastrointestinal tract. This blocks the action of serotonin, a major trigger for nausea and vomiting.

Contraindications of Ondansetron Injection:

• Hypersensitivity or allergy to Ondansetron or any of its components.

• Congenital long QT syndrome.

• Concurrent use with apomorphine (risk of severe hypotension and loss of consciousness).

Drug Interactions of DOVION  Injection:

• QT-Prolonging Drugs: Combining Ondansetron with medications like amiodarone or sotalol increases the risk of QT prolongation.

• CYP3A4 Inducers/Inhibitors: Drugs that affect liver enzymes (e.g., phenytoin, carbamazepine, or rifampin) may reduce Ondansetron's efficacy.

• Serotonergic Drugs: Increased risk of serotonin syndrome when combined with SSRIs, SNRIs, or MAO inhibitors.

• Tramadol: Ondansetron may reduce the analgesic effect of tramadol.

Precautions of Ondansetron Injection:

• Use with caution in patients with electrolyte imbalances (e.g., hypokalemia or hypomagnesemia).

• Monitor ECG in patients at risk of QT prolongation.

• Safe for use in pregnancy only if clearly indicated (Category B).

For proper use and safety, always consult a healthcare professional before starting Ondansetron.

For Use of Registered Medical Practitioner or A Hospital Only

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