LINXO 600 Tablet
Linezolid 600 mg Tablet Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions...
LINXO 600 Tablet (Linezolid 600 mg)
Linezolid is a Prescription Drug Used as an Antibiotic to Treat Certain Serious Bacterial Infections. It Works By Stopping The Growth Of Bacteria.
LINXO 600 Tablet is an antibiotic medicine used in the treatment of severe bacterial infections. It is used to treat infections of lungs (Pneumonia), skin and soft tissues.
Linxo 600 Tablet (Linezolid 600 mg) is an antibiotic medication used primarily for the treatment of bacterial infections.
1. Uses & Indications:
Linxo 600 (Linezolid 600 mg) is used for the treatment of serious bacterial infections. It is effective against both Gram-positive and some Gram-negative bacteria, especially those resistant to other antibiotics, such as:
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Pneumonia (community-acquired or hospital-acquired)
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Skin and soft tissue infections (including diabetic foot infections)
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Vancomycin-resistant Enterococcus faecium (VRE) infections
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Methicillin-resistant Staphylococcus aureus (MRSA) infections
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Infections caused by Streptococcus and Staphylococcus species
It is typically used when other antibiotics are not effective or when the bacteria are resistant to standard treatment options.
2. Mechanism of Action:
Linezolid works by inhibiting bacterial protein synthesis. It does so by binding to the bacterial ribosome (specifically the 23S rRNA of the 50S subunit), preventing the formation of a functional initiation complex, which is necessary for protein synthesis. This halts bacterial growth and replication, leading to bacterial death.
Linezolid is a bacteriostatic agent against most organisms, but it can also be bactericidal against certain strains, such as Streptococcus pneumonia.
3. Dosage:
The typical dosage of Linxo 600 is as follows:
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Adult Dosage:
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Initial Dose: 600 mg orally, twice a day.
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Duration: Duration depends on the infection type and clinical response, but typically ranges from 10 to 14 days.
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Pediatric Dosage: The dosage may vary depending on the child’s weight, condition, and doctor’s recommendations.
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Renal or Hepatic Impairment: For patients with severe renal or hepatic impairment, dosage adjustments may be necessary.
It’s important to follow the prescribing physician's instructions, as the exact dosage and duration depend on the infection type and patient condition.
4. Side Effects:
Common side effects of Linxo 600 include:
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Gastrointestinal: Diarrhea, nausea, vomiting, and constipation.
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Hematologic: Low platelet count (thrombocytopenia), low white blood cell count (leukopenia), anemia.
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Neurological: Headaches, dizziness, and peripheral neuropathy (numbness or tingling sensation in the hands or feet).
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Liver Effects: Elevations in liver enzymes (liver toxicity).
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Skin reactions: Rash or itching.
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Serotonin Syndrome: Rare but severe when combined with certain antidepressants.
If side effects like persistent diarrhea or signs of an allergic reaction occur, seek medical attention promptly.
5. Contraindications:
Linxo 600 is contraindicated in the following situations:
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Hypersensitivity: In case of known allergy to Linezolid or any of its ingredients.
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Use with Monoamine Oxidase Inhibitors (MAOIs): Linezolid has weak MAOI activity, so concurrent use with MAOIs or within 14 days of stopping them is contraindicated due to the risk of hypertensive crisis.
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Severe renal or hepatic impairment: Dosage adjustments are necessary, and in some cases, it may be contraindicated.
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Pheochromocytoma (a rare tumor of the adrenal glands): Linezolid can increase blood pressure.
6. Drug Interactions:
Several drugs can interact with Linezolid, leading to increased side effects or reduced efficacy:
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Serotonergic Drugs: Linezolid has MAOI properties, so combining it with SSRIs (e.g., fluoxetine, sertraline), SNRIs (e.g., venlafaxine), or other Serotonergic drugs may lead to serotonin syndrome, which is a potentially life-threatening condition.
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Adrenergic Drugs: The combination of Linezolid with medications like pseudoephedrine, phenylephrine, or epinephrine may lead to increased blood pressure.
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Antibiotics: Certain antibiotics, like rifampin, can interfere with the effectiveness of Linezolid. Care should be taken if used with other antibacterial medications.
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Anti-platelet or Anticoagulants: As Linezolid can cause thrombocytopenia, combining it with drugs that affect platelets (e.g., aspirin, clopidogrel, and warfarin) could increase bleeding risk.
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Anesthetics: If used with certain anesthetics like halothane, caution is advised due to potential effects on blood pressure.
Consult with your healthcare provider or pharmacist before starting or combining Linezolid with any other medications to avoid serious interactions.
For Use of Registered Medical Practitioner or A Hospital Only
