Lorazepam 2 mg Tablet Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions....

ZOPS 2 Tablet (Lorazepam 2 mg) 

Use and Indications:

Zops 2 Tablet (Lorazepam) is primarily used for the treatment of anxiety and related conditions. 

1. Anxiety Disorders: To manage generalized anxiety disorder (GAD) and short-term anxiety.
2. Panic Disorder: To alleviate acute panic attacks.
3. Insomnia: When it is caused by anxiety or stress.
4. Preoperative Anxiety: To calm patients before surgery.
5. Seizures: Used as a part of the management of acute seizures (such as status epilepticus).
6. Alcohol Withdrawal: To reduce symptoms of alcohol withdrawal.

Mechanism of Action:

Lorazepam works by enhancing the effect of GABA (gamma-aminobutyric acid), which is a neurotransmitter that inhibits neural activity. By increasing GABA activity, Lorazepam produces a calming effect on the brain and nervous system. This helps to reduce anxiety, promote sedation, and prevent seizures.

Dosage:

• Adult Dosage for Anxiety: 1-3 mg per day, divided into 2-3 doses.
• Adult Dosage for Insomnia: Typically, 2-4 mg before bedtime.
• Adult Dosage for Panic Attacks: Usually, 2 mg twice a day.
• Preoperative Sedation: 1-2 mg before surgery.

Dosage varies based on the individual’s medical condition, age, and other factors. It is essential to follow the specific dosing instructions provided by the healthcare provider.

Side Effects:

Common side effects of Lorazepam include:

• Drowsiness or sedation
• Dizziness or lightheadedness
• Fatigue
• Blurred vision
• Headache
• Muscle weakness

More severe side effects may include:

• Memory problems or confusion
• Coordination problems
• Respiratory depression (especially when combined with other CNS depressants)
• Mood changes or depression
• Addiction or dependence (especially with long-term use)

Seek immediate medical attention if any of the severe side effects occur.

Contraindications:

Lorazepam should not be used in the following conditions:

• Hypersensitivity: Known allergy to Lorazepam or other benzodiazepines.
• Severe Respiratory Insufficiency: In patients with severe breathing problems.
• Sleep Apnea Syndrome: Where breathing stops during sleep.
• Acute Narrow-Angle Glaucoma: A condition that affects the eyes.
• Severe Hepatic Impairment: Patients with severe liver dysfunction.

Drug Interactions:

Lorazepam can interact with several drugs, leading to enhanced sedative effects or potentially dangerous side effects. Some notable interactions include:

• Alcohol: Excessive sedation and respiratory depression can occur when taken with alcohol.
• CNS Depressants (e.g., barbiturates, other benzodiazepines, opioids, or antipsychotics): Can increase sedation, leading to severe drowsiness or respiratory issues.
• Antidepressants: Such as fluoxetine or paroxetine, this can alter the metabolism of lorazepam.
• Anticonvulsants: When combined with drugs like Phenytoin or carbamazepine, the effect of Lorazepam may be altered.
• Cimetidine: An antacid that can increase Lorazepam levels in the blood.

Always inform the prescribing doctor about other medications being taken, including over-the-counter drugs and supplements.

For Use of registered medical practitioner or a hospital only

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