ZOPS 2 TAB

Lorazepam 2 mg Tablet

USES OF LORAZEPAM 2MG:

Lorazepam is used as a short-term (2-4 weeks) therapy for anxiety, or sleeping difficulties due to anxiety. It may also be used to relax a patient before surgery including dental surgery.

SIDE EFFECTS OF LORAZEPAM 2MG:

Drowsiness, headache, dizziness, confusion; blurred vision; nausea; weakness; unsteadiness. Potentially Fatal: Respiratory depression.

DRUG INTERACTIONS OF LORAZEPAM 2MG:

Potentiation of CNS depression produced by alcohol; general anaesthetics; narcotic analgesics; TCAs; MAOIs; phenothiazines; antipsychotics; barbiturates; scopolamine.

CONTRAINDICATIONS OF LORAZEPAM 2MG:

Severe hepatic impairment; respiratory depression; acute narrow-angle glaucoma; pregnancy and lactation.

MECHANISM OF ACTION OF LORAZEPAM 2MG:

Lorazepam is a short acting benzodiazepine. Lorazepam enhances the inhibitory effect of GABA on neuronal excitability by modulating GABAA receptors. Onset: Hypnosis: 20-30 min (IM); sedation: 5-20 min (IV); anticonvulsant: 5 min (IV), 30-60 min (oral). Duration: 6-8 hr. Absorption: Readily absorbed (oral, IM); peak plasma concentrations after 2 hr. Distribution: Crosses the placenta and blood-brain barrier; enters breast milk. Protein-binding: 85%. Metabolism: Hepatic; converted to inactive metabolites. Excretion: Urine and faeces; 10-20 hr (elimination half-life).

SPECIAL PRECAUTIONS FOR LORAZEPAM 2MG:

Hepatic and renal dysfunction; pulmonary insufficiency; myasthenia gravis; may impair ability to drive or operate machinery; elderly or debilitated patients.

FOR USE OF REGISTERED MEDICAL PRACTITIONER OR A HOSPITAL ONLY.