ESODASS LS CAPSULE
Esomeprazole 40 mg,Levosulpiride 75 mg capsule Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions...
ESODASS LS CAPSULE
Each hard gelatin Capsule contaions: Esomeprazole Magnesium IP Eq to Esomeprazole 40 mg (as Enteric Coated Pellets),Levosulpiride 75 mg (as Sustained Release Pellets)
Esomeprazole 40 mg
Use (Indication):
- Esomeprazole is primarily used to treat conditions related to excessive stomach acid production, such as:
- Gastroesophageal reflux disease (GERD)
- Peptic ulcer disease
- Zollinger-Ellison syndrome (a rare condition causing excessive stomach acid)
Dosage:
- The typical dosage for Esomeprazole in adults is 20 mg to 40 mg once daily. The dose can vary based on the condition being treated and the severity.
Mechanism of Action:
- Esomeprazole is a proton pump inhibitor (PPI) that works by reducing the production of stomach acid. It blocks the enzyme system (H+/K+ ATPase) that produces acid in the stomach, thereby decreasing acid secretion.
Side Effects:
- Common side effects may include headache, diarrhea, nausea, abdominal pain, and flatulence.
- Less common but more serious side effects may include severe allergic reactions, severe diarrhea, and vitamin B12 deficiency with long-term use.
Drug Interactions:
- Esomeprazole may interact with medications metabolized by the liver enzymes CYP2C19 and CYP3A4, such as diazepam, warfarin, and certain antifungal drugs. It can also reduce the absorption of drugs that require acidic pH for optimal absorption.
Contraindications:
- Esomeprazole should generally be avoided or used with caution in individuals with known hypersensitivity to PPIs or any component of the formulation.
Levosulpiride 75 mg
Use (Indication):
- Levosulpiride is primarily used in the treatment of:
- Gastroesophageal reflux disease (GERD)
- Irritable bowel syndrome (IBS)
- Functional dyspepsia (indigestion without a known cause)
- Psychiatric conditions such as depression and anxiety (in some countries)
Dosage:
- The usual dosage of Levosulpiride is 25 mg to 75 mg daily, depending on the condition being treated and the patient's response.
Mechanism of Action:
- Levosulpiride acts as a dopamine D2 receptor antagonist and also has some affinity for serotonin receptors. It primarily modulates gastrointestinal motility and reduces nausea and vomiting.
Contraindications:
- Levosulpiride is contraindicated in patients with a known hypersensitivity to sulpiride or any component of the formulation. It should be used with caution in patients with renal impairment.
Side Effects:
- Common side effects may include headache, dizziness, insomnia, gastrointestinal disturbances (such as constipation or diarrhea), and prolactin elevation (which can lead to breast enlargement or lactation in some individuals).
Drug Interactions:
- Levosulpiride may interact with medications that affect dopamine levels or other psychiatric medications. It is important to consult with a healthcare provider to avoid potential interactions.
Combination Therapy of ESODASS LS CAPSULE
When Esomeprazole 40 mg and Levosulpiride 75 mg are prescribed together, the combination is likely aimed at treating conditions where both acid suppression and gastrointestinal motility modulation are necessary, such as severe GERD with delayed gastric emptying or functional dyspepsia with acid-related symptoms.
Always consult with a healthcare provider for specific dosage recommendations, potential drug interactions, and guidance on managing side effects.
For Use of Registered Medical Practitioner or A Hospital Only