YODON PLUS TABLET

Each Uncoated Tablet Contains:

Domperidone IP 20 mg
Paracetamol IP 500 mg Tablet

DOMPERIDONE 20 MG + PARACETAMOL (ACETAMINOPHEN) 500 MG is used to treat migraine. It prevents pain signals to reach the brain to reduce pain. It also blocks certain substances in the brain that trigger nausea or vomiting during migraine headaches.

 

MECHANISM OF ACTION OF DOMPERIDONE 20MG + PARACETAMOL 500MG(YODON PLUS TABLET):

DOMPERIDONE IS A DOPAMINE ANTAGONIST WHICH WORKS TO PREVENT VOMITING (SYMPTOM OF MIGRAINE). DOMPERIDONE IS GIVEN WITH PARACETAMOL, AN ANALGESIC, FOR RELIEF OF MIGRAINE.

 

SIDE EFFECTS OF DOMPERIDONE 20MG + PARACETAMOL 500MG (YODON PLUS TABLET):

DROWSINESS, EXTRAPYRAMIDAL REACTIONS, GALACTORRHOEA, GYNAECOMASTIA; CONSTIPATION OR DIARRHOEA, LASSITUDE, DECREASED LIBIDO, NAUSEA, ALLERGIC REACTIONS, SKIN RASHES, ACUTE RENAL TUBULAR NECROSIS. POTENTIALLY FATAL: DOMPERIDONE: CONVULSIONS, ARRHYTHMIAS AND CARDIAC ARREST, DYSRHYTHMIAS IN PATIENTS WITH CV DISEASE OR HYPOKALAEMIA, PATIENTS ON CANCER CHEMOTHERAPY. SEIZURES, HYPERTENSIVE CRISIS IN PATIENTS WITH PHEOCHROMOCYTOMA ARE SEEN. PARACETAMOL, VERY RARE, BLOOD DYSCRASIAS (EG, THROMBOCYTOPAENIA, LEUCOPAENIA, NEUTROPAENIA, AGRANULOCYTOSIS); LIVER DAMAGE ARE SEEN.

DRUG INTERACTIONS OF DOMPERIDONE 20MG + PARACETAMOL 500MG(YODON PLUS TABLET):

DOMPERIDONE REDUCES ABSORPTION OF ORAL DIGOXIN, INCREASES ABSORPTION OF ASPIRIN AND ORAL DIAZEPAM. ENHANCES CNS DEPRESSION BY PHENOTHIAZINES. ANTIMUSCARINIC AGENTS AND OPIOIDS ANTAGONISE GI EFFECTS OF DOMPERIDONE. PARACETAMOL REDUCED ABSORPTION OF CHOLESTYRAMINE WITHIN 1 HR OF ADMIN AND ACCELERATES ABSORPTION OF METOCLOPRAMIDE. POTENTIALLY FATAL: PARACETAMOL INCREASES THE RISK OF LIVER DAMAGE IN CHRONIC ALCOHOLICS. INCREASED RISK OF TOXICITY WITH OTHER HEPATOTOXIC DRUGS OR DRUGS WHICH INDUCE MICROSOMAL ENZYMES.

CONTRAINDICATIONS OF DOMPERIDONE 20MG + PARACETAMOL 500MG (YODON PLUS TABLET):

HYPERSENSITIVITY. GI HAEMORRHAGE, OBSTRUCTION AND PERFORATION, PATIENTS WITH PROLACTIN RELEASING PITUITARY HORMONE OR CHRONIC ADMIN OR FOR PROPHYLAXIS OF POSTOPERATIVE NAUSEA AND VOMITING.

SPECIAL PRECAUTIONS FOR DOMPERIDONE 20MG + PARACETAMOL 500MG(YODON PLUS TABLET):

PHAEOCHROMOCYTOMA; CHILDREN, ELDERLY; RENAL OR HEPATIC IMPAIRMENT, RISK OF CARDIAC ARRHYTHMIAS AND HYPOKALAEMIA IF ADMINISTERED IV. PREGNANCY, LACTATION AND ALCOHOL-DEPENDENT PATIENTS.

 

For Use of registered medical practitioner or a hospital only.