Cefpodoxime 50 mg ,Clavulanic acid 31.25 mg/ 5 ml Dry Syrup with sterile Water Use, Indication, Side Effects, Dosage, Mechanism of Action, Price, Contra-Indications, Drug Interactions As Description....

Spinxo Clav Dry Syrup

Each 5 mL of Reconstituted suspension contains:

Cefpodoxime 50 mg ,Clavulanic acid 31.25 mg (30ml) Bottle with water for injection 

Indication / Uses :

Spinxo Clav Dry Syrup is primarily used for the treatment of bacterial infections. It is a combination antibiotic that is effective against a variety of bacterial pathogens. It is commonly prescribed for:

• Excellent Coverage Against Gram +Ve And Gram –Ve Pathogens

• Respiratory infections (e.g., bronchitis, pneumonia)

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

• Ear infections (otitis media)

• Sinusitis

• Kills Even ESBL Producing Pathogens

• Gastro Intestinal Tract Infection

• Cervicitis Meningitis

The combination of Cefpodoxime, a third-generation cephalosporin, and Clavulanic acid, a beta-lactamase inhibitor, enhances the effectiveness against bacteria that produce beta-lactamase enzymes, which would otherwise degrade the antibiotic.

Mechanism of Action:

Cefpodoxime: It is a broad-spectrum, third-generation cephalosporin that works by inhibiting the bacterial cell wall synthesis. This leads to the weakening and eventual lysis of the bacterial cell wall, effectively killing the bacteria.

Clavulanic acid: It works by inhibiting beta-lactamase enzymes that bacteria secrete to break down antibiotics. By preventing this breakdown, clavulanic acid enhances the activity of cefpodoxime against beta-lactamase-producing bacteria.

Together, the combination allows the medication to treat a wider range of infections.

Dosage:

Adults and children over 12 years of age: The usual dose is 5 ml of the reconstituted syrup (equivalent to 50 mg of cefpodoxime and 31.25 mg of clavulanic acid) twice daily. The exact dosage depends on the type and severity of the infection.

Children (under 12 years): The dosage is adjusted according to the child’s weight and the severity of the infection. A pediatrician should determine the appropriate dosage.

For optimal absorption, it's usually recommended to take the medication with food.

Note: Always follow the prescribed dosage by a healthcare provider.

Side Effects:

Common side effects of Spinxo Clav Dry Syrup may include:

• Gastrointestinal symptoms like nausea, vomiting, diarrhea, or abdominal pain

• Allergic reactions, including skin rashes, itching, or swelling

• Headache

• Dizziness

• Fatigue

Serious side effects (rare) may include:

• Severe allergic reactions (anaphylaxis)

• Liver dysfunction (jaundice, elevated liver enzymes)

• Clostridium difficile-associated diarrhea (a serious form of diarrhea)

• Seizures (in cases of overdose or kidney dysfunction)

If any severe side effects are noticed, immediate medical attention should be sought.

Contraindications:

• Hypersensitivity (allergic reactions) to cefpodoxime, clavulanic acid, or any other cephalosporin antibiotics.

• Severe liver disease: Spinxo Clav should be used cautiously in patients with liver problems.

• History of jaundice or liver dysfunction related to antibiotic use.

• Kidney impairment: Dose adjustments may be necessary in individuals with impaired kidney function.

Drug Interactions:

• Probenecid: Can increase the levels of cefpodoxime in the blood.

• Anticoagulants (e.g., warfarin): Cefpodoxime may increase the anticoagulant effect, raising the risk of bleeding.

• Other antibiotics: Using cefpodoxime with other antibiotics can alter its effectiveness, especially in the case of bacteriostatic antibiotics (e.g., tetracyclines).

• Diuretics: Use with diuretics may increase the risk of nephrotoxicity.

• Oral contraceptives: Antibiotics like cefpodoxime might reduce the efficacy of birth control pills, increasing the risk of pregnancy.

Always inform your doctor about other medications you are currently taking to avoid potential interactions.

Storage:

Store the syrup in a cool, dry place, away from direct sunlight.

After reconstitution (mixing with water), store the syrup in the refrigerator and use within 7 to 14 days, as per the manufacturer’s instructions.

 

For Use of registered medical practitioner or a hospital only

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