Hetrofen Sp Tablet

Aceclofenac 100 Mg, Paracetamol 325 Mg,Serratiopeptidase (Ec)15 Mg Tablet (Fc)

Hetrofen Sp Tablet Is Orally Administered For The Relief Of Pain And Inflammation In Osteoarthritis, Rheumatoid Arthritis And Ankylosing Spondylitis.

Uses Of Aceclofenac 100mg + Paracetamol 325mg + Serratiopeptidase 15 Mg (Hetrofen Sp Tablet):

It Is Prescribed For Fever, Various Kinds Of Pain And Arthritis .

Side Effects Of Aceclofenac 100mg + Paracetamol 325mg + Serratiopeptidase 15 Mg (Hetrofen Sp Tablet):

Serratiopeptidase: Nausea, Allergic Reactions, Skin Rashes, Acute Renal Tubular Necrosis

Aceclofenac: Diarrhoea, Headache, Vertigo, Dizzies, Nervousness, Tinnitus, Depression, Drowsiness, Insomnia; Fever, Angioedema, Bronchospasm, Rashes; Blood Dyscrasias. Potentially Fatal, Severe Gi Bleeding; Nephrotoxicity

Paracetamol: Very Rare, Blood Dyscrasias (Eg, Thrombocytopaenia, Leucopaenia, Neutropaenia, Agranulocytosis); Liver Damage.

Drug Interactions Of Aceclofenac 100mg + Paracetamol 325mg + Serratiopeptidase 15 Mg (Hetrofen Sp Tablet):

Paracetamol: Reduced Absorption Of Cholestyramine Within 1 Hr Of Administration. Accelerated Absorption With Metoclopramide. Aceclofenac:

May Increase The Plasma Concentrations Of Lithium And Digoxin. Increased Nephrotoxicity With Diuretics. Serum-Potassium Should Be Monitored When Used With Potassium-Sparing Diuretics.

May Enhance Activity Of Anticoagulants.

May Increase Plasma Methotrexate Levels Leading To Toxicity If Administered Within 2-4 Hr Of Methotrexate Admin.

Risk Of Convulsions With Quinolones. Potentially Fatal:

Paracetamol: Increased Risk Of Liver Damage In Chronic Alcoholics. Increased Risk Of Toxicity With High Doses Or Long Term Admin Of Barbiturates, Carbamazepine, Hydantoins, Isoniazid, Rifampin And Sulfinpyrazone.

Contraindications Of Aceclofenac 100mg + Paracetamol 325mg + Serratiopeptidase 15 Mg (Hetrofen Sp Tablet):

Hypersensitivity. Moderate To Severe Renal Or Hepatic Impairment; Severe Heart Failure; Pregnancy (Third Trimester).

Mechanism Of Action Of Aceclofenac 100mg + Paracetamol 325mg + Serratiopeptidase 15 Mg (Hetrofen Sp Tablet):

Aceclofenac Is A Phenylacetic Acid Derivative That Inhibits Synthesis Of The Inflammatory Cytokines Interleukin-1b And Tumour Necrosis Factor, And Inhibits Prostaglandin E2 Production. It Increases Glycosaminoglycans (Gag) Synthesis, The Principal Macromolecule Of The Extracellular Matrix, Which Aids In Repair And Regeneration Of Articular Cartilage. Thus, Aceclofenac Has +Ve Effects On Cartilage Anabolism Combined With Modulating Effect Of Matrix Catabolism.

Paracetamol Has Analgesic And Antipyretic Action With Weak Anti-Inflammatory Activity. It Produces Analgesia By Increasing Pain Threshold And Antipyresis By Acting On The Hypothalamic Heat-Regulating Centre. Absorption: Aceclofenac: Rapidly Absorbed; Almost 100% Bioavailability; Peak Plasma Levels Reached About 1.25-3 Hr After Oral Admin. Distribution: Aceclofenac: >99.7% Bound To Plasma Proteins; Distributes Into Synovial Fluid. Paracetamol: Distributes Throughout Most Fluids Of The Body. Metabolism: Aceclofenac: Probably Metabolised By Cyp2c9; Average Plasma Elimination Half-Life: 4-4.3 Hr. Paracetamol: Mainly Metabolised Hepatically; Plasma Elimination Half-Life: 1-4 Hr. Excretion: Aceclofenac: About Two-Thirds Of The Administered Dose Is Removed In The Urine, Mainly As Conjugated Hydroxymetabolites. Paracetamol: Most Metabolites Are Removed In The Urine Within 24 Hr.

Special Precautions For Aceclofenac 100mg + Paracetamol 325mg + Serratiopeptidase 15 Mg (Hetrofen Sp Tablet):

Gi Disease; Renal Or Hepatic Impairment; Alcohol-Dependent Patients; Asthma Or Allergic Disorders; Haemorrhagic Disorders; Hypertension; Cardiac Impairment. Elderly. Caution When Driving Or Operating Machinery. Monitor Renal And Hepatic Function And Blood Counts During Long Term Treatment. Persistently Elevated Hepatic Enzyme Levels May Require Drug Withdrawal. Pregnancy, Lactation.

Packing : 10 Tablet In Alu Alu Pack (10*10 Outer Carton)

What Is The Use Of Aceclofenac Paracetamol And Serratiopeptidase Tablets? 

Is Serratiopeptidase A Painkiller?  Which Is Better Ibuprofen Or Aceclofenac?

What Is Serratiopeptidase Used For? 

Is Aceclofenac Used For Toothache?

For Use Of Registered Medical Practitioner Or A Hospital Only