ROXYPIR 20 TABLET

Piroxicam 20 mg Tablet

Piroxicam is used to reduce pain, swelling, and joint stiffness from arthritis.Reducing these symptoms helps you do more of your normal daily activities.

Piroxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Piroxicam is in a class of medications called NSAIDs.

MECHANISM OF ACTION OF PIROXICAM 20MG (ROXYPIR 20 TABLET):

PIROXICAM IS A NSAID, BELONGING TO THE OXICAM GROUP. IT INHIBITS PROSTAGLANDIN SYNTHESIS, REDUCES FEVER BY ACTING ON THE HEAT-REGULATING CENTER OF THE HYPOTHALAMUS, INHIBITS PLATELET-AGGREGATING SUBSTANCE THROMBOXANE A2 AND REDUCES PAIN RECEPTOR SENSITIVITY. IT ALSO EXERTS ANTI-INFLAMMATORY EFFECT BY LYSOSOMAL STABILISATION, KININ AND LEUKOTRIENE PRODUCTION, ALTERATION OF CHEMOTACTIC FACTORS AND NEUTROPHIL ACTIVATION INHIBITION. ABSORPTION: WELL ABSORBED FROM THE GIT (ORAL); PEAK PLASMA CONCENTRATIONS 3-5 HR AFTER AN ORAL DOSE. DISTRIBUTION: DETECTED IN BREAST MILK. PROTEIN-BINDING: 99% METABOLISM: HEPATIC VIA HYDROXYLATION AND CONJUGATION; UNDERGOES ENTEROHEPATIC RECYCLING. EXCRETION: MAINLY IN URINE (AS METABOLITES AND UNCHANGED DRUG), FAECES; ELIMINATION HALF-LIFE: 50 HR.

SPECIAL PRECAUTIONS FOR PIROXICAM 20MG (ROXYPIR 20 TABLET):

ELDERLY, CHILDN <12 YR. PATIENTS WITH INFECTIONS, ASTHMA, ALLERGIC DISORDERS, HAEMORRHAGIC DISORDERS OR HYPERTENSION. IMPAIRED RENAL, HEPATIC OR CARDIAC FUNCTION. MONITOR FOR SIGNS OF LIVER, KIDNEY, BLOOD OR EYE DISORDERS.

SIDE EFFECTS OF PIROXICAM 20MG (ROXYPIR 20 TABLET):

GI DISTURBANCES, PEPTIC ULCER, GI BLEEDING, HEADACHE, DIZZINESS, BLURRED VISION, TINNITUS, SKIN RASHES AND PRURITUS. HAEMATOLOGICAL CHANGES AND PHOTOSENSITIVITY. POTENTIALLY FATAL: THROMBOCYTOPAENIA AND ACUTE NEPHROPATHY. TOXIC EPIDERMAL NECROLYSIS AND STEVENS-JOHNSON SYNDROME.

DRUG INTERACTIONS OF PIROXICAM 20MG (ROXYPIR 20 TABLET):

INCREASED RISK OF HYPERKALAEMIA WHEN USED WITH ACE INHIBITORS AND POTASSIUM-SPARING DIURETICS. CONVULSIONS MAY OCCUR WHEN USED WITH QUINOLONES. EFFECTS OF PHENYTOIN AND SULFONYLUREAS MAY BE ENHANCED. ANTIHYPERTENSIVE EFFECTS OF ACE INHIBITORS, β-BLOCKERS AND DIURETICS MAY BE REDUCED. INCREASED RISK OF GI BLEEDING AND ULCERATION WHEN USED WITH CORTICOSTEROIDS, SSRIS OR ANTIPLATELET AGENTS. INCREASED RISK OF HAEMATOTOXICITY WHEN USED WITH ZIDOVUDINE. ACE INHIBITORS, CICLOSPORIN, TACROLIMUS OR DIURETICS MAY INCREASE NEPHROTOXICITY. POTENTIALLY FATAL: MAY POTENTIATE ANTICOAGULANTS. INCREASED LEVELS OF LITHIUM, METHOTREXATE AND CARDIAC GLYCOSIDES.

CONTRAINDICATIONS OF PIROXICAM 20MG (ROXYPIR 20 TABLET):

HYPERSENSITIVITY, ACTIVE PEPTIC ULCERATION, PORPHYRIA, PREGNANCY (3RD TRIMESTER) AND LACTATION.

FOR USE OF REGISTERED MEDICAL PRACTITIONER OR A HOSPITAL ONLY